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Robert T Dorr Selected Research

4- imino- 1,3- diazabicyclo(3.1.0)hexan- 2- one

6/2016Magnetic Resonance Imaging Identifies Differential Response to Pro-Oxidant Chemotherapy in a Xenograft Model.
8/2014Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma.
6/2012Tumor Xenograft Response to Redox-Active Therapies Assessed by Magnetic Resonance Imaging Using a Thiol-Bearing DOTA Complex of Gadolinium.
4/2012Anti-tumor activity and mechanism of action for a cyanoaziridine-derivative, AMP423.
3/2012Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells.
9/2011Interaction of dacarbazine and imexon, in vitro and in vivo, in human A375 melanoma cells.
1/2011Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase.
7/2010A phase I study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer.
2/2009Inhibition of protein synthesis by imexon reduces HIF-1alpha expression in normoxic and hypoxic pancreatic cancer cells.
5/2007Imexon-based combination chemotherapy in A375 human melanoma and RPMI 8226 human myeloma cell lines.
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Robert T Dorr Research Topics

Disease

21Neoplasms (Cancer)
06/2016 - 08/2003
9Pancreatic Neoplasms (Pancreatic Cancer)
01/2015 - 01/2005
7Multiple Myeloma
12/2013 - 01/2002
4Necrosis
06/2013 - 01/2006
4Melanoma (Melanoma, Malignant)
09/2011 - 04/2007
3Prostatic Neoplasms (Prostate Cancer)
12/2013 - 06/2007
3Lymphoma (Lymphomas)
05/2012 - 12/2003
2Colonic Neoplasms (Colon Cancer)
06/2013 - 04/2005
2Erythema
07/2004 - 08/2003
1Hyperoxia
06/2016
1Hypercapnia
06/2016
1Hypersensitivity (Allergy)
01/2015
1Non-Hodgkin Lymphoma (Lymphosarcoma)
08/2014
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2013
1Inflammation (Inflammations)
05/2012
1B-Cell Lymphoma (Lymphoma, B Cell)
04/2012
1Adenocarcinoma
07/2010
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
11/2009
1Hypoxia (Hypoxemia)
02/2009
1Skin Neoplasms (Skin Cancer)
01/2008
1Cardiotoxicity
12/2007
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
12/2007
1Multiple Sclerosis
12/2007

Drug/Important Bio-Agent (IBA)

164- imino- 1,3- diazabicyclo(3.1.0)hexan- 2- oneIBA
06/2016 - 01/2002
7Reactive Oxygen Species (Oxygen Radicals)IBA
06/2016 - 11/2006
6Sulfhydryl Compounds (Thiols)IBA
06/2016 - 01/2004
5Antineoplastic Agents (Antineoplastics)IBA
12/2013 - 11/2002
4Pharmaceutical PreparationsIBA
06/2012 - 01/2006
4Proteins (Proteins, Gene)FDA Link
04/2012 - 12/2002
3GemcitabineFDA Link
01/2015 - 07/2010
3Bortezomib (Velcade)FDA Link
06/2013 - 05/2005
2Contrast MediaIBA
06/2016 - 06/2012
2OxazolesIBA
12/2013 - 11/2009
25- (4- methoxyphenyl)- 2- (3- (3- methoxyphenyl)pyridin- 4- yl)oxazoleIBA
12/2013 - 11/2009
2Glutathione (Reduced Glutathione)IBA
06/2012 - 03/2012
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
05/2012 - 07/2006
2Vincristine (Oncovin)FDA LinkGeneric
05/2012 - 07/2006
2GlucocorticoidsIBA
05/2012 - 07/2006
2Doxorubicin (Adriamycin)FDA LinkGeneric
05/2012 - 07/2006
2aziridine (ethyleneimine)IBA
07/2010 - 01/2002
2UA 62784IBA
11/2009 - 01/2009
2Mitoxantrone (Novantrone)FDA LinkGeneric
12/2007 - 06/2007
2anthraceneIBA
12/2007 - 06/2007
22- (2'- (dimethylamino)ethyl)- 1,2- dihydro- 7- ethoxydibenz(de,h)isoquinoline- 1,3- dioneIBA
12/2007 - 06/2007
2Type II DNA Topoisomerases (Topoisomerase II)IBA
06/2007 - 12/2002
2Proteasome InhibitorsIBA
05/2007 - 05/2005
1Biomarkers (Surrogate Marker)IBA
06/2016
1Histone Deacetylase InhibitorsIBA
01/2015
1Histone Deacetylases (Histone Deacetylase)IBA
01/2015
1HeterochromatinIBA
01/2015
1TubulinIBA
12/2013
1Nelfinavir (Viracept)FDA Link
06/2013
1CalpainIBA
06/2013
1CaspasesIBA
06/2013
1HIV Protease InhibitorsIBA
06/2013
13-((4-benzylpiperazino)methyl)-1H-indoleIBA
06/2013
1AlbuminsIBA
06/2012
1mercury orangeIBA
06/2012
1Buthionine SulfoximineIBA
06/2012
1gadodiamide (Omniscan)FDA Link
06/2012
11,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA
06/2012
1GadoliniumIBA
06/2012
1AntioxidantsIBA
05/2012
1EnzymesIBA
05/2012
1AMP423IBA
04/2012
1Peptide Initiation Factors (Initiation Factor)IBA
03/2012
1Dacarbazine (DIC)FDA LinkGeneric
09/2011
1Drug CombinationsIBA
01/2011
1tyrosine receptor (receptor, tyrosine)IBA
11/2009
1Phosphotransferases (Kinase)IBA
11/2009
1Protein Kinases (Protein Kinase)IBA
11/2009
1centromere protein EIBA
11/2009
1KinesinsIBA
11/2009
1Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
11/2009
1Sulfates (Sulfates, Inorganic)IBA
08/2009
1Acetates (Acetic Acid Esters)FDA Link
08/2009
1Masoprocol (Actinex)FDA Link
08/2009
1CarbonatesIBA
08/2009
1terameprocolIBA
08/2009
1Oxygen (Dioxygen)IBA
02/2009
1Antimitotic AgentsIBA
01/2009
1perillyl alcoholIBA
01/2008
1Therapeutic UsesIBA
12/2007
1Immunosuppressive Agents (Immunosuppressants)IBA
12/2007
1Integrin alpha6IBA
11/2007
1IntegrinsIBA
11/2007
1quinone (benzoquinone)IBA
06/2007
1hydroquinone (Esoterica)FDA Link
06/2007
1PoisonsIBA
06/2007
1Dexamethasone (Maxidex)FDA LinkGeneric
05/2007
1thiazolyl blueIBA
05/2007
1lissamine rhodamine B (sulforhodamine B)IBA
05/2007
1apomine (SR 45023A)IBA
04/2007
1EstersIBA
04/2007
1Caspase 3 (Caspase-3)IBA
04/2007

Therapy/Procedure

7Therapeutics
06/2016 - 12/2003
1Drug Therapy (Chemotherapy)
05/2012
1Regimen B
07/2010
1Chemoprevention
01/2008
1Combination Drug Therapy (Combination Chemotherapy)
05/2007